Association of Consangiunity, Ethincity and Addiction with Clubfoot in Pakistan

Authors

  • Anisuddin Bhatti, Department of Orthopaedic & Trauma Surgery Jinnah Postgraduate Medical Centre Karachi, Pakistan Author
  • Muhammad Yousuf Bhatti Department of Orthopaedic & Trauma Surgery Jinnah Postgraduate Medical Centre Karachi, Pakistan Author
  • Muhammad Faizan Ali Department of Orthopaedic & Trauma Surgery Jinnah Postgraduate Medical Centre Karachi, Pakistan Author

Keywords:

Clubfoot, Consanguinity, Ethincity, and Addiction

Abstract

Objective: To determine the association of clubfoot with consanguinity, ethnicity, lunar eclipse and addictions.

Methods: This observational descriptive case series study was conducted from July 2013 to December 2013. All 200 idiopathic clubfoot patients, who reported at Clubfoot Clinic (CFC) were included in the study. A designed questionnaire was used for asking questions from parents on telephone and during their visit to CFC

Results: Eighty-five (42.5%) patients were born from consanguineous marriage and 115 (57.5%) from non- consanguineous marriage. (p<0.001) 10 out of 115 consanguineous marriage were non- Muslim, who do not marry cousins (p<0.001) Two mothers had a history of smoking during pregnancy, 16 had a habit of chewing Paan (beetle nut & tobacco). None of the mothers had exposure to lunar /solar eclipse.

Conclusion: The Club Foot has a strong association with consanguine marriages, with heterogenic geographical distribution and family history and no association to exposure with lunar eclipse. Association with addiction (cigarette smoking tobacco chewing & paan), could not be identified due to insufficient data.

Key Words: Clubfoot, Consanguinity, Ethincity, and Addiction

References

1.Alvarado DM, Aferol H, McCall Kenin, Hauang JB, Techy M, Buchan J, Cady JG, Dobbs M, Gurnett CA. Familial isolated Clubfoot is Associated with Reccurent Chromosome 17q23. 1q23.2 Microduplication containing TBx4. Am J Hum Genet; 2010,37:154 –159. 2.Penny N. The neglected clubfoot. Technologies Orthopaed, 2005; 20:153–166 3.Delivering health saving lives. The state of the world Midwifery: Pakistan. 2011. unfpa.org/public/home/publications/pid/10765: 120–121. 4.Pakistan Demographic and Health Survey, 2012-2013. National institute of population studies. Measure DHS. ICF international. Calveron. 2013. 5.Ukoha U, Egwu OA., Okafor IJ , Udemezue OO, Olisah R, Anyabolu AE. Incidence of congenital Talipes equinoverus among children in southeast Nigeria – Int J Biol Med Res.2011; 2:712-715. 6.Wallander H, Hovelius L, MichaeLsson K. Incidence of congenital club foot in Sweden Acta Orthop 2006;77: 847-852. 7.Lochmiller C, Johnston D., Scott A., Risman M, Hecht JT., Genetic epidemiology Study of idiopathictalipes Equino varus Am J Med. Genet 1998: 79:90:96. 8.Krogsgaard MR, Tesen PK, Kajaer I., Husted H, Lorentzen J, Hvass CB, Christensen SB, Laesen K, Sonne HS. : Increasing incidence clubfoot with higher Population density. Incidence and geographical Variation in Denmark over a 16 years period – an epidmilogy study of 936625 birth. Acta Orthop 2006; 77:839-846. 9.Fischgrund JS. Lower limbs & foot disorders pediatrics in orthopaedic knowledge update AAOS 2008. Ch 61.741-803. 10.Kawashima T, Uhthoff HK. Development of the foot in prenatal life in rotation to idiopathic clubfoot1990;10:232 – 237. 11.Ponseti IV Congenital Clubfoot. Fundamentals of treatment. New York Oxford University Press 1996. 12.Tachdjian. Congenital Equinorarus (Clubfoot) in Tachdjian’s Pediatric Orthopaedics 4th Ed. Saunders. Canada 2008:1070 –1110. 13.Zosia M. Congenital Telipes equno vorm (Club foot) : a disorder of foot but not the hand J Anat 2003; 202: 37-42. 14.Wynne DR. Genetic and environmental factors the etiology of TEV. Clin Orthop 1972; 84:9-13. 15.Chapman C, Scott NS, Port RV, Nichol RO. Genetics of clubfoot in Maori and Pacific people. J Med Genet. 2000;37:680-683. 16.Alper ÖM, Erengin H, Manguo AE, Bilgen T, Çetin Z, Dedeo lu N, et al. Consanguineous marriages in the province of Antalya, Turkey. Annales deGénétique, 2004 Jun; 47(2):129-138. 17.Young I, Clarke M. Lethal malformations and perinatal mortality: a 10- year review with comparison of ethnic differences. Br Med J 1987 Jul; 295:89-91. 18.Søgaard M, Vedsted-Jakobsen A. Consanguinity and congenital abnormalities. Ugeskr Laeger. 2003 Apr;165(18):1851-1855. 19.Sorouri A. Consanguineous marriage and congenital anomalies. First edition, Isfahan University of Medical Sciences, 1380:1-15. 20.Khlat M, Khoury M. Consanguinity and diseases: Demographic, Genetic, and epidemiologic perspectives. Epidemiologic reviews 1991; 13:28-30. 21.Tayebi N Yazdani K Naghshin N The prevalence of Congenital mal formation & its correlation with consanguineous marriages Oman Med J 2010; 25:37 – 40. 22.Sreenivas T, et al. Parental consanguinity and associated factors in congenital talipes equinovarus. Foot (Edinb). 2012,22(1):2-5. doi: 10.1016/j.foot.2011.08.001. Epub 2011 Sep 15. 23.Sahin O, et al. Consanguineous marriage and increased risk of idiopathic congenital talipes equinovarus: a case-control study in a rural area. J Pediatr Orthop. 2013; 33:333-338. 24.Ganjwala D. Management of Clubfoot. In Orthopaedic & Trauma, 2nd Ed., Kulkarni DS, Ed. Jaypee brothers, New Delhi; 2008:3121–3144. 25.Wynne Dr. Familial studies and causes of congenital clubfoot, Talipes Equino Varus, Talipes Calcaneovalgus and metatarsus varus. J. Bone Joint surg. 1964, 46:B: 445–463.

Downloads

Published

2015-11-02

How to Cite

Association of Consangiunity, Ethincity and Addiction with Clubfoot in Pakistan. (2015). Journal of Pakistan Orthopaedic Association, 27(3), 101-104. https://mail.jpoa.org.pk/index.php/upload/article/view/163

Similar Articles

1-10 of 14

You may also start an advanced similarity search for this article.