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CTX1 is A Better Index to Evaluate The Severity of Osteoporosis then Radiographic Index
Abstract
Objective: To illustrate that CTX1 is the far better tool to evaluate the severity of osteoporosis then radiographic index (Singh index) in perimenopausal women. Material and Methods: This descriptive cross sectional study was done on 100 subjects, in the tertiary referral health care facilities of Peshawar via PGMI Hayatabad Medical Complex, Peshawar, Pakistan. The study was done in six months’ time period. Levels of CTX1 as a marker of bone degradation in radiographically assessed perimenopausal women were determined. These females were randomly selected and screened for osteoporosis. Radiographic grade of osteoporosis according to Singh index as 1-6 and CTX 1 level in pg/ml was taken. Results: High levels of CTX1 were observed in perimenopausal osteoporotic women, which were radiographically normal. Conclusion: The results of this study propose that CTX1 levels are the more reliable tool for assessing osteoporosis as compared to radiographic index.
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2. Declining Rates of Osteoporosis Management Following Fragility Fractures in the U.S., 2000 Through 2009. AkhilaBalasubramanian, PhD; Laura L. Tosi, MD; Joseph M. Lane, MD; Douglas R. Dirschl, MD; Pei-Ran Ho, MD; Cynthia D. O’Malley, PhD. J Bone Joint Surg Am, 2014 Apr 02;96(7):e52.
3. Osteoporosis Disease Management: The Role of the Orthopaedic Surgeon Richard Dell, MD; Denise Greene, RNP, MS; Steven R. Schelkun, MD; Kathy Williams, MSG J Bone Joint Surg Am, 2008 Nov;90(Supplement 4):188-194.
4. Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, Dilsen G, Gennari C, Lopes Vaz A, Lyritis G, et al. Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study.J Bone Miner Res. Nov(1995);10(11):1802-15.
5. Fatima M , Nawaz H , Kassi m , Rehman R , Kasi Pm. Determining the risk factors and prevalence of osteoporosis using qualitative ultrasonography in Pakistani adult women. Singapore Med J 2009 ;50(1):20
6. Frederick R, Singer MD, David R , Eyre. Using biochemical markers in bone turnover in clinical practice. Clv Ind. Clnj Med 2008 (75) :739-749.
7. Vasikaran SD. Utility of biochemical markers of bone turnover and bone mineral density in management of osteoporosis. Crit Rev Clin Lab Sci (2008) 45:221–258.
8. Chailurkit La-or , S Ongphiphadhanakul B, Jongjaroenprasert W, Sae-Tung S, and Rajatanavin R (2001). Biochemical Markers of Bone Turnover and Response of Bone Mineral Density to Intervention in Early Postmenopausal Women: An Experience in a Clinical Laboratory. Clin Chem.2001 (47):1083-1087.
9. Wright PE II. Singh Index for osteoporosis. In: Campbell WC, Canale ST, Beaty JH, eds. Campbell’s Operative Orthopaedics.11th ed: (2008) 4299– 4230.
10. Osten L Junggren and Sverker L Junghall. Carboxy terminal peptide of type 1 collagen ICTP as a marker of matrix degradation in neonatal mouse calvarial bones in vitro. Bisciences Report. 1992 12 ( 5).
11. Rosen H N, Moses AC, Garber J, Iloputaife ID, Ross DS, Lee SL, Greenspan SL,(2000) Serum CTX: a new marker of bone resorption that shows treatment
effect more often than other markers because of low coefficient of variability and large changes with bisphosphonate therapy, Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, Massachusetts, USA.
12. Pramudito J.T, Soegijoko S., Mengko T.R., Muchtadi F.I., Wachjudi R.G. Trabecular Pattern Analysis of Proximal Femur Radiographs for Osteoporosis Detection. Journal of Biomedical & Pharmaceutical Engineering 1:1 (2007) 45-51 ISSN: 1793-4532.
13. Paul Gerdhem , Kaisa K Ivaska , sari L Alatalo, jussi M Haleen, JukkaHelman, Anders Isaksson. Biochemical markers of bone metabolism and prediction of fracture in elderly women .journal of bone and mineral research .200419 (3) 386-393.
14. Martin AR, Sornay-Rendu E, Chandler JM, Duboeuf F, Girman CJ, Delmas PD The impact of osteoporosis on quality-of-life: the OFELY cohort. Bone.2002 Jul;31(1):32-6.
15. Robin JA, AM Schott, P Garnevo, P D Delmas . Risk factors for hip fractures in women with high BMD. Epidos study; Osteoporosis Int.(2005) 16; 149-154.
16. S.Vasikaran, R Eastell, O Bruyere, AJ Foldes , P.Garnero, A Grieshmacher et al. Markers of bone turnover for prediction of fracture risk and monitoring of osteoporosis treatment : a need for international reference standards. Osteoporosis Int 2011(22) 391-420
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Published
2015-03-30
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Original Articles
How to Cite
CTX1 is A Better Index to Evaluate The Severity of Osteoporosis then Radiographic Index. (2015). Journal of Pakistan Orthopaedic Association, 27(1), 41-46. https://mail.jpoa.org.pk/index.php/upload/article/view/237
